Characteristics of doripenem: a new broad-spectrum antibiotic

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Characteristics of doripenem: a new broad-spectrum antibiotic

Doripenem (S-4661) is a new parenteral antibiotic from the carbapenem class; similarly to imipenem and meropenem, it has a broad-spectrum activity against Gram-positive, Gram-negative, and anaerobic bacteria. It is active against multiresistant Gram-negative bacilli such as extended-spectrum beta-lactamase-producing (ESBL) Gram-negative Enterobacteriaceae and nonfermentative Gram-negative bacil...

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DDDT-3083-Characteristics of doripenem: a new broad-spectrum

Correspondence: Francisco Alvarez-Lerma intensive Care Unit, Hospital del Mar, Passeig Marítim, 25-29, 08003, Barcelona, Spain Tel +34 93 248 3125 Fax +34 93 248 3254 email [email protected] Abstract: Doripenem (S-4661) is a new parenteral antibiotic from the carbapenem class; similarly to imipenem and meropenem, it has a broad-spectrum activity against Gram-positive, Gram-negative, and ana...

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Doripenem: a new carbapenem antibiotic.

PURPOSE The chemistry, pharmacology, antimicrobial activity, pharmacokinetics, pharmacodynamics, efficacy and safety in humans, and formulary considerations of doripenem are reviewed. SUMMARY Doripenem, a member of the β-lactam class of antibiotics, is the newest addition to the carbapenems. It exhibits concentration-independent bactericidal activity against gram-positive bacteria; enteric an...

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ژورنال

عنوان ژورنال: Drug Design, Development and Therapy

سال: 2009

ISSN: 1177-8881

DOI: 10.2147/dddt.s3083